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Dataset Description
  • Dataset Name: 11141048
  • Species: Human
  • Method: Microarray
  • No. of Genes: 135
  • Tissue: Frontal cortex
  • Phenotype: Alcohol dependence (AD)/Alcohol abuse/Alcoholism
  • Publication: Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
  • Dataset Summary: RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

    Gene list of this dataset (135 genes)
    GeneIDSymbolNameGenetic locationOriginal ID1Original ID2
    1195CLK1CDC-like kinase 12q33AA044407 
    2670GFAPglial fibrillary acidic protein17q21AA059335 
    6210RPS15Aribosomal protein S15a16pAA102395 
    78986DUSP26dual specificity phosphatase 26 (putative)8p12AA167722 
    5865RAB3BRAB3B, member RAS oncogene family1p32-p31AA235116 
    55320C14orf106chromosome 14 open reading frame 10614q21.3AA283901 
    56888KCMF1potassium channel modulatory factor 12p11.2AA313794 
    100129239CXorf51chromosome X open reading frame 51Xq27.3AA417208 
    90843TCEAL8transcription elongation factor A (SII)-like 8Xq22.1AA424109 
        AA436947 
    124402FAM100Afamily with sequence similarity 100, member A16p13.3AA679059 
    23209MLC1megalencephalic leukoencephalopathy with subcortical cysts 122q13.33AA703765 
    51195RAPGEFL1Rap guanine nucleotide exchange factor (GEF)-like 117q21.1-q21.2AA707689 
        AA912329 
    11011TLK2tousled-like kinase 217q23AB004884 
    23316CUX2cut-like homeobox 212q24.11-q24.12AB006631 
    6712SPTBN2spectrin, beta, non-erythrocytic 211q13AB008567 
    23259DDHD2DDHD domain containing 28p12AB018268 
        AC002550 
    5977DPF2D4, zinc and double PHD fingers family 211q13AF001433 
    10106CTDSP2CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 212q13-q15AF022231 
    1196CLK2CDC-like kinase 21q21AF023268 
        AF038201 
    5901RANRAN, member RAS oncogene family12q24.3AF052578 
    5901RANRAN, member RAS oncogene family12q24.3AF054183 
    6422SFRP1secreted frizzled-related protein 18p12-p11.1AF056087 
    11170FAM107Afamily with sequence similarity 107, member A3p21.1AF089853 
    27075TSPAN13tetraspanin 137p21.1AF120265 
    8851CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)17q11.2AI003191 
        AI004627 
    8642DCHS1dachsous 1 (Drosophila)11p15.4AI018181 
    7159TP53BP2tumor protein p53 binding protein, 21q42.1AI123916 
    57184C15orf17chromosome 15 open reading frame 1715q24.1AI306588 
    11145HRASLS3HRAS-like suppressor 311q12.3-q13.1AI375733 
        AI375991 
    6414SEPP1selenoprotein P, plasma, 15q31AI521556 
    5999RGS4regulator of G-protein signaling 41q23.3AI651602 
    10133OPTNoptineurin10p13AI669775 
    10085EDIL3EGF-like repeats and discoidin I-like domains 35q14AI677769 
    51090PLLPplasma membrane proteolipid (plasmolipin)16q13AI683914 
    2949GSTM5glutathione S-transferase M51p13.3AI797367 
    100131540LOC100131540-9q22.1AI801966 
    51330TNFRSF12Atumor necrosis factor receptor superfamily, member 12A16p13.3AI827127 
        AI831729 
    1824DSC2desmocollin 218q12.1AI888282 
    10715LASS1LAG1 homolog, ceramide synthase 119p12AI936592 
    400745SH2D5SH2 domain containing 51p36.12AI937119 
    825CAPN3calpain 3, (p94)15q15.1-q21.1AI978885 
    326AIREautoimmune regulator21q22.3AJ009610 
    7529YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide20q13.1AL008725 
    6375XCL1chemokine (C motif) ligand 11q23AL031736 
    9363RAB33ARAB33A, member RAS oncogene familyXq25D14889 
    8019BRD3bromodomain containing 39q34D26362 
    5695PSMB7proteasome (prosome, macropain) subunit, beta type, 79q34.11-q34.12D38048 
    23208SYT11synaptotagmin XI1q21.2D38522 
    23180RFTN1raftlin, lipid raft linker 13p24.3D42043 
    9798KIAA0174KIAA017416q22.3D79996 
    10439OLFM1olfactomedin 19q34.3D82343 
    4753NELL2NEL-like 2 (chicken)12q13.11-q13.12D83018 
    23176SEPT8septin 85q31D86957 
    9783RIMS3regulating synaptic membrane exocytosis 31pter-p22.2D87074 
    5046PCSK6proprotein convertase subtilisin/kexin type 615q26.3D87993 
    11170FAM107Afamily with sequence similarity 107, member A3p21.1F13434 
    2052EPHX1epoxide hydrolase 1, microsomal (xenobiotic)1q42.1J03518 
    808CALM3calmodulin 3 (phosphorylase kinase, delta)19q13.2-q13.3J04046 
    3916LAMP1lysosomal-associated membrane protein 113q34J04182 
    7385UQCRC2ubiquinol-cytochrome c reductase core protein II16p12J04973 
    3326HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 16p12J04988 
    183AGTangiotensinogen (serpin peptidase inhibitor, clade A, member 8)1q42-q43K02215 
    6622SNCAsynuclein, alpha (non A4 component of amyloid precursor)4q21L08850 
    6252RTN1reticulon 114q23.1L10333 
    5048PAFAH1B1platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa17p13.3L13385 
    723790HIST2H2AA4histone cluster 2, H2aa41q21.2L19779 
    3306HSPA2heat shock 70kDa protein 214q24.1L26336 
    9414TJP2tight junction protein 2 (zona occludens 2)9q13-q21L27476 
    6921TCEB1transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)8q21.11L34587 
    10262SF3B4splicing factor 3b, subunit 4, 49kDa1q12-q21L35013 
    3853KRT6Akeratin 6A12q12-q13L42611 
    5168ENPP2ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)8q24.1L46720 
    5796PTPRKprotein tyrosine phosphatase, receptor type, K6q22.2-q22.3L77886 
    6175RPLP0ribosomal protein, large, P012q24.2M17885 
    4069LYZlysozyme (renal amyloidosis)12q15M19045 
    3329HSPD1heat shock 60kDa protein 1 (chaperonin)2q33.1M22382 
    7316UBCubiquitin C12q24.3M26880 
    5532PPP3CBprotein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform10q21-q22M29551 
    5567PRKACBprotein kinase, cAMP-dependent, catalytic, beta1p36.1M34181 
    1493CTLA4cytotoxic T-lymphocyte-associated protein 42q33M37245 
    1191CLUclusterin8p21-p12M63379 
    4134MAP4microtubule-associated protein 43p21M64571 
    2890GRIA1glutamate receptor, ionotropic, AMPA 15q33|5q31.1M64752 
    377ARF3ADP-ribosylation factor 312q13M74491 
    1465CSRP1cysteine and glycine-rich protein 11q32M76378 
    5730PTGDSprostaglandin D2 synthase 21kDa (brain)9q34.2-q34.3M98539 
    79145CHCHD7coiled-coil-helix-coiled-coil-helix domain containing 78q12.1N76371 
    2561GABRB2gamma-aminobutyric acid (GABA) A receptor, beta 25q34S67368 
    10628TXNIPthioredoxin interacting protein1q21.1S73591 
    6662SOX9SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)17q24.3-q25.1S74506 
    3428IFI16interferon, gamma-inducible protein 161q22S75433 
    7018TFtransferrin3q22.1S95936 
    6506SLC1A2solute carrier family 1 (glial high affinity glutamate transporter), member 211p13-p12U01824 
    2202EFEMP1EGF-containing fibulin-like extracellular matrix protein 12p16U03877 
    4905NSFN-ethylmaleimide-sensitive factor17q21U03985 
    2617GARSglycyl-tRNA synthetase7p15U09587 
    6157RPL27Aribosomal protein L27a11p15U14968 
    4799NFX1nuclear transcription factor, X-box binding 19p13.3U15306 
    84939MUM1melanoma associated antigen (mutated) 119p13.3U20908 
    4485MST1macrophage stimulating 1 (hepatocyte growth factor-like)3p21U28054 
    5176SERPINF1serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 117p13.1U29953 
    6563SLC14A1solute carrier family 14 (urea transporter), member 1 (Kidd blood group)18q11-q12U35735 
    6258RXRGretinoid X receptor, gamma1q22-q23U38480 
    358AQP1aquaporin 1 (Colton blood group)7p14U41517 
    3766KCNJ10potassium inwardly-rectifying channel, subfamily J, member 101q22-q23U52155 
    27333GOLIM4golgi integral membrane protein 43q26.2U55853 
    1016CDH18cadherin 18, type 25p15.2-p15.1U59325 
    5653KLK6kallikrein-related peptidase 619q13.3U62801 
    7113TMPRSS2transmembrane protease, serine 221q22.3U75329 
    5625PRODHproline dehydrogenase (oxidase) 122q11.21U82381 
    398ARHGDIGRho GDP dissociation inhibitor (GDI) gamma16p13.3U82532 
    11332ACOT7acyl-CoA thioesterase 71p36.31-p36.11U91316 
    6588SLNsarcolipin11q22-q23U96094 
    3125HLA-DRB3major histocompatibility complex, class II, DR beta 36p21.3V00522 
    677809SNORA24small nucleolar RNA, H/ACA box 244q26W05842 
    3122HLA-DRAmajor histocompatibility complex, class II, DR alpha6p21.3X00274 
    2597GAPDHglyceraldehyde-3-phosphate dehydrogenase12p13X01677 
    826CAPNS1calpain, small subunit 119q13.12X04106 
    1345COX6Ccytochrome c oxidase subunit VIc8q22-q23X13238 
    655BMP7bone morphogenetic protein 720q13X51801 
    2697GJA1gap junction protein, alpha 1, 43kDa6q21-q23.2X52947 
    960CD44CD44 molecule (Indian blood group)11p13X55150 
    10971YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide2p25.1X56468 
    4005LMO2LIM domain only 2 (rhombotin-like 1)11p13X61118 
    5524PPP2R4protein phosphatase 2A activator, regulatory subunit 49q34X73478 
    529ATP6V1E1ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E122pter-q11.2|22q11.1X76228 
    539ATP5OATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein)21q22.1-q22.2|21q22.11X83218 
    6879TAF7TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa5q31X97999 
    6185RPN2ribophorin II20q12-q13.1Y00282 
    5654HTRA1HtrA serine peptidase 110q26.3Y07921 
    2861GPR37G protein-coupled receptor 37 (endothelin receptor type B-like)7q31Y12476 
    5590PRKCZprotein kinase C, zeta1p36.33-p36.2Z15108 
    780DDR1discoidin domain receptor tyrosine kinase 16p21.3Z29093 
    6834SURF1surfeit 19q34.2Z35093 
    4076CAPRIN1cell cycle associated protein 111p13Z48042 
    54557SGTBsmall glutamine-rich tetratricopeptide repeat (TPR)-containing, beta5q12.3Z99387