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Dataset Description
  • Dataset Name: 11141048
  • Species: Human
  • Method: Microarray
  • No. of Genes: 135
  • Tissue: Frontal cortex
  • Phenotype: Alcohol dependence (AD)/Alcohol abuse/Alcoholism
  • Publication: Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
  • Dataset Summary: RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

    Gene list of this dataset (135 genes)
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    GeneIDSymbolNameGenetic locationOriginal ID1Original ID2
    6375XCL1chemokine (C motif) ligand 11q23AL031736 
    9363RAB33ARAB33A, member RAS oncogene familyXq25D14889 
    8019BRD3bromodomain containing 39q34D26362 
    5695PSMB7proteasome (prosome, macropain) subunit, beta type, 79q34.11-q34.12D38048 
    23208SYT11synaptotagmin XI1q21.2D38522 
    23180RFTN1raftlin, lipid raft linker 13p24.3D42043 
    9798KIAA0174KIAA017416q22.3D79996 
    10439OLFM1olfactomedin 19q34.3D82343 
    4753NELL2NEL-like 2 (chicken)12q13.11-q13.12D83018 
    23176SEPT8septin 85q31D86957 
    9783RIMS3regulating synaptic membrane exocytosis 31pter-p22.2D87074 
    5046PCSK6proprotein convertase subtilisin/kexin type 615q26.3D87993 
    11170FAM107Afamily with sequence similarity 107, member A3p21.1F13434 
    2052EPHX1epoxide hydrolase 1, microsomal (xenobiotic)1q42.1J03518 
    808CALM3calmodulin 3 (phosphorylase kinase, delta)19q13.2-q13.3J04046 
    3916LAMP1lysosomal-associated membrane protein 113q34J04182 
    7385UQCRC2ubiquinol-cytochrome c reductase core protein II16p12J04973 
    3326HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 16p12J04988 
    183AGTangiotensinogen (serpin peptidase inhibitor, clade A, member 8)1q42-q43K02215 
    6622SNCAsynuclein, alpha (non A4 component of amyloid precursor)4q21L08850 
    6252RTN1reticulon 114q23.1L10333 
    5048PAFAH1B1platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa17p13.3L13385 
    723790HIST2H2AA4histone cluster 2, H2aa41q21.2L19779 
    3306HSPA2heat shock 70kDa protein 214q24.1L26336 
    9414TJP2tight junction protein 2 (zona occludens 2)9q13-q21L27476 
    6921TCEB1transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)8q21.11L34587 
    10262SF3B4splicing factor 3b, subunit 4, 49kDa1q12-q21L35013 
    3853KRT6Akeratin 6A12q12-q13L42611 
    5168ENPP2ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)8q24.1L46720 
    5796PTPRKprotein tyrosine phosphatase, receptor type, K6q22.2-q22.3L77886 
    6175RPLP0ribosomal protein, large, P012q24.2M17885 
    4069LYZlysozyme (renal amyloidosis)12q15M19045 
    3329HSPD1heat shock 60kDa protein 1 (chaperonin)2q33.1M22382 
    7316UBCubiquitin C12q24.3M26880 
    5532PPP3CBprotein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform10q21-q22M29551 
    5567PRKACBprotein kinase, cAMP-dependent, catalytic, beta1p36.1M34181 
    1493CTLA4cytotoxic T-lymphocyte-associated protein 42q33M37245 
    1191CLUclusterin8p21-p12M63379 
    4134MAP4microtubule-associated protein 43p21M64571 
    2890GRIA1glutamate receptor, ionotropic, AMPA 15q33|5q31.1M64752 
    377ARF3ADP-ribosylation factor 312q13M74491 
    1465CSRP1cysteine and glycine-rich protein 11q32M76378 
    5730PTGDSprostaglandin D2 synthase 21kDa (brain)9q34.2-q34.3M98539 
    79145CHCHD7coiled-coil-helix-coiled-coil-helix domain containing 78q12.1N76371 
    2561GABRB2gamma-aminobutyric acid (GABA) A receptor, beta 25q34S67368 
    10628TXNIPthioredoxin interacting protein1q21.1S73591 
    6662SOX9SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)17q24.3-q25.1S74506 
    3428IFI16interferon, gamma-inducible protein 161q22S75433 
    7018TFtransferrin3q22.1S95936 
    6506SLC1A2solute carrier family 1 (glial high affinity glutamate transporter), member 211p13-p12U01824 
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