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Gene Information
Gene ID:10133
Full Name:optineurin
Organism:Homo sapiens (Human)
Genetic Location:10p13
Physical Location:13182087-13220281 on NC_000010.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AI669775
Fold Change:1.4, 1.6
Note:Differential Expression on the cDNA array (two fold changes are from two case groups)
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001008211.1NP_001008212.1NC_000010.9 range: 13182087..13220281
NM_001008212.1NP_001008213.1NC_000010.9 range: 13182087..13220281
NM_001008213.1NP_001008214.1NC_000010.9 range: 13182087..13220281
NM_021980.4NP_068815.2NC_000010.9 range: 13182087..13220281
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentTAS (9488477)
GO:0005794Golgi apparatusCellular ComponentIDA (15837803)
GO:0008022protein C-terminus bindingMolecular FunctionIPI (15837803)
GO:0000042protein targeting to GolgiBiological ProcessIMP (15837803)
GO:0007030Golgi organization and biogenesisBiological ProcessIMP (15837803)
GO:0007165signal transductionBiological ProcessTAS (9488477)
GO:0008219cell deathBiological ProcessTAS (9488477)
GO:0043001Golgi to plasma membrane protein transportBiological ProcessIMP (15837803)
Other Database Cross Links
NCBI Entrez Gene:10133
HuGE Navigator:10133