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Gene Information
Gene ID:11011
Symbol:TLK2
Full Name:tousled-like kinase 2
Alias:MGC44450|PKU-ALPHA
Organism:Homo sapiens (Human)
Chromosome:17
Genetic Location:17q23
Physical Location:57910135-58044758 on NC_000017.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AB004884
Fold Change:-1.9, -1.5
Note:Differential Expression on the cDNA array (two fold changes are from two case groups)
Dataset Information
Name:11141048
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_006852.3NP_006843.2NC_000017.9 range: 57910135..58044758
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentNAS
GO:0005634nucleusCellular ComponentIEP (9427565)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIDA (12660173)
GO:0005515protein bindingMolecular FunctionIPI (17353931)
GO:0004674protein serine/threonine kinase activityMolecular FunctionNAS (9427565|10523312)
GO:0004674protein serine/threonine kinase activityMolecular FunctionIDA (12660173)
GO:0016740transferase activityMolecular FunctionIEA
GO:0001672regulation of chromatin assembly or disassemblyBiological ProcessIDA (12660173)
GO:0006468protein amino acid phosphorylationBiological ProcessIDA (12660173)
GO:0006974response to DNA damage stimulusBiological ProcessIEA
GO:0007049cell cycleBiological ProcessIEA
GO:0007242intracellular signaling cascadeBiological ProcessIDA (12660173)
GO:0016568chromatin modificationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:11011
HGNC:11842
Ensembl:ENSG00000146872
MIM:608439
HPRD:10527
HuGE Navigator:11011
dbSNP:TLK2
GeneCard:TLK2
AceView:TLK2