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Gene Information
Gene ID:1195
Symbol:CLK1
Full Name:CDC-like kinase 1
Alias:CLK|CLK/STY|STY
Organism:Homo sapiens (Human)
Chromosome:2
Genetic Location:2q33
Physical Location:201425977-201437666 on NC_000002.10, complement
Gene Type:protein-coding
Orthologs:This gene has Mouse: 12747 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AA044407
Fold Change:-1.5, -1.6
Note:Differential Expression on the cDNA array (two fold changes are from two case groups)
Dataset Information
Name:11141048
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Linkage Dataset
MarkerLODP valueLocation (bp)
D2S117  195326948
Region:195326948-216757195
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Name:15211641
Method:Linkage
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_004071.2NP_004062.2NC_000002.10 range: 201425977..201437666, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0004674protein serine/threonine kinase activityMolecular FunctionIEA
GO:0004674protein serine/threonine kinase activityMolecular FunctionTAS (1825055)
GO:0004715non-membrane spanning protein tyrosine kinase activityMolecular FunctionTAS (1825055)
GO:0005524ATP bindingMolecular FunctionIEA
GO:0016740transferase activityMolecular FunctionIEA
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0008283cell proliferationBiological ProcessTAS (1704889)
Other Database Cross Links
NCBI Entrez Gene:1195
HGNC:2068
Ensembl:ENSG00000013441
MIM:601951
HPRD:09058
HuGE Navigator:1195
dbSNP:CLK1
GeneCard:CLK1
AceView:CLK1