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Gene Information
Gene ID:148
Full Name:adrenergic, alpha-1A-, receptor
Organism:Homo sapiens (Human)
Genetic Location:8p21-p11.2
Physical Location:26661583-26778838 on NC_000008.9, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:ADRA1A
Dataset Information
Method:Addiction array gene list
Publication:Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000680.2NP_000671.2NC_000008.9 range: 26661583..26778838, complement
NM_033302.2NP_150645.2NC_000008.9 range: 26661583..26778838, complement
NM_033303.3NP_150646.3NC_000008.9 range: 26661583..26778838, complement
NM_033304.2NP_150647.2NC_000008.9 range: 26661583..26778838, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005886plasma membraneCellular ComponentIEA
GO:0005887integral to plasma membraneCellular ComponentTAS (8396931)
GO:0001584rhodopsin-like receptor activityMolecular FunctionIEA
GO:0004937alpha1-adrenergic receptor activityMolecular FunctionTAS (7737411)
GO:0004937alpha1-adrenergic receptor activityMolecular FunctionNAS (9490024)
GO:0004935adrenoceptor activityMolecular FunctionIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0007267cell-cell signalingBiological ProcessTAS (8396931)
GO:0007243protein kinase cascadeBiological ProcessTAS (10671514)
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessTAS (10860850)
GO:0007165signal transductionBiological ProcessTAS (8396931)
GO:0006939smooth muscle contractionBiological ProcessTAS (8183249)
GO:0006915apoptosisBiological ProcessTAS (10671514)
GO:0008285negative regulation of cell proliferationBiological ProcessTAS (10860850)
Other Database Cross Links
NCBI Entrez Gene:148
HuGE Navigator:148