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Gene Information
Gene ID:14828
Full Name:heat shock protein 5
Organism:Mus musculus (Mouse)
Genetic Location:2 B|2 22.5 cM
Physical Location:34627614-34631976 on NC_000068.6
Gene Type:protein-coding
Human Ortholog:GeneID: 3309    Symbol (Name): HSPA5 (heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa))
Ortholog Status:The human GeneID 3309 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hspa5
Original ID2:AJ002387
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Alcp1Alcohol Preference Drinking22819-35 (cM)5.3 SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_022310.2NP_071705.2NC_000068.6 range: 34627614..34631976
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005783endoplasmic reticulumCellular ComponentIDA (7679955|12646573|12826667|14960307|15294975|15452145)
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (12065409|14960307)
GO:0005524ATP bindingMolecular FunctionIEA
GO:0043022ribosome bindingMolecular FunctionIDA (12065409)
GO:0006950response to stressBiological ProcessIEA
GO:0006983ER overload responseBiological ProcessIDA (11854325)
Other Database Cross Links
NCBI Entrez Gene:14828