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Gene Information
Gene ID:17475
Full Name:multiple PDZ domain protein
Organism:Mus musculus (Mouse)
Genetic Location:4 C3|4 38.6 cM
Physical Location:80924403-81088708 on NC_000070.5, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 8777    Symbol (Name): MPDZ (multiple PDZ domain protein)
Ortholog Status:The human GeneID 8777 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Mpdz
Original ID2:AJ131869
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Information
Original ID1:1418664 (probe)
Original ID2:Mpdz
Fold Change:1.28
P Value:4.30E-06
Note:Highest priority differential expression on 430A array. Direction: B6>D2; Cis LOD:9
Gene Information
Original ID1:93887 (probe)
Original ID2:Mpdz
Fold Change:1.57
P Value:1.10E-06
Note:Moderate priority differential expression on U74Av2 array. Direction: B6>D2; Cis LOD:0.9
Dataset Information
Method:Microarray and QTL
Phenotype:Acute ethanol withdrawal, Chronic ethanol withdrawal, Ethanol preference drinking, Ethanol-stimulated activity
Publication:Hitzemann et al. Alcohol Clin Exp Res. (2004) On the integration of alcohol-related quantitative trait loci and gene expression analyses. PubMed
Summary:Six ethanol-related QTLs, all detected in C57BL/6J and DBA/2J intercrosses were entered into the analysis.Brain gene expression data for the C57BL/6 and DBA/2 strains (n=6 per strain) and an F2 intercross sample (n=56) derived from these strains were obtained by using the Affymetrix U74Av2 and 430A arrays; additional data with the U74Av2 array were available for the extended amygdala, dorsomedial striatum, and hippocampus.Within the 6 QTL intervals, 39 transcripts (430A array) were identified as being highly likely to be differentially expressed between the C57BL/6 and DBA/2 strains at a false discovery rate of 0.01 or better. The p value is from the t test comparison between the C57BL/6J (B6) and DBA/2J (D2) inbred strains. The phenotype of each gene are based on the QTL phenotype.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Alcw2Acute Alcohol Withdrawal43838-38.7 (cM)8.82.00E-10SignificantPARC
Caws2Chronic Alcohol Withdrawal4 33-51 (cM)2.30.005SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_010820.2NP_034950.2NC_000070.5 range: 80924403..81088708, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005923tight junctionCellular ComponentIDA (11689568)
GO:0016020membraneCellular ComponentIEA
GO:0019717synaptosomeCellular ComponentIEA
GO:0030054cell junctionCellular ComponentIEA
GO:0042995cell projectionCellular ComponentIEA
GO:0045202synapseCellular ComponentIEA
GO:0045211postsynaptic membraneCellular ComponentIEA
GO:0005515protein bindingMolecular FunctionIPI (11689568)
GO:0007155cell adhesionBiological ProcessIDA (11689568)
Other Database Cross Links
NCBI Entrez Gene:17475