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Gene Information
Gene ID:18516
Full Name:pre B-cell leukemia transcription factor 3
Organism:Mus musculus (Mouse)
Genetic Location:2 B|2 22.0 cM
Physical Location:34027428-34227555 on NC_000068.6, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 5090    Symbol (Name): PBX3 (pre-B-cell leukemia homeobox 3)
Ortholog Status:The human GeneID 5090 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Pbx3
Original ID2:AF020200
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
QTL Information
QTLPhenotypeChrPeak (cM)LODP ValueRangeStatusQTL Link
Alcp1Alcohol Preference Drinking22819-35 (cM)5.3 SignificantPARC
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_016768.1NP_058048.1NC_000068.6 range: 34027428..34227555, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIDA (15466398)
GO:0005667transcription factor complexCellular ComponentIDA (15466398)
GO:0003677DNA bindingMolecular FunctionIEA
GO:0003700transcription factor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (15466398)
GO:0043565sequence-specific DNA bindingMolecular FunctionIDA (16847320)
GO:0007585respiratory gaseous exchangeBiological ProcessIMP (15466398)
GO:0007388posterior compartment specificationBiological ProcessRCA (12466851)
GO:0007387anterior compartment specificationBiological ProcessRCA (12466851)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0006350transcriptionBiological ProcessIEA
GO:0045449regulation of transcriptionBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:18516