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Gene Information
Gene ID:2561
Symbol:GABRB2
Full Name:gamma-aminobutyric acid (GABA) A receptor, beta 2
Alias:MGC119386|MGC119388|MGC119389
Organism:Homo sapiens (Human)
Chromosome:5
Genetic Location:5q34
Physical Location:160648013-160907707 on NC_000005.8, complement
Gene Type:protein-coding
Orthologs:This gene has Mouse: 14401 Rat: 25451 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:S67368
Fold Change:-1.7, -1.4
Note:Differential expression on the oligonucleotide array (two fold changes are from two case groups)
Dataset Information
Name:11141048
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Gene Information
Original ID1:GABRB2
Dataset Information
Name:18477577
Method:Addiction array gene list
Publication:Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.
Gene Information
Original ID1:GABRB2
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Information
Original IDNo. of PublicationsPhenotype
GABRB25Alcoholism
GABRB24Alcohol-Related Disorders
HuGE Navigator Dataset
Name:HuGE Navigator
Method:Literature data mining
Publication:Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000813.2NP_000804.1NC_000005.8 range: 160648013..160907707, complement
NM_021911.2NP_068711.1NC_000005.8 range: 160648013..160907707, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0045211postsynaptic membraneCellular ComponentIEA
GO:0045202synapseCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentIEA
GO:0005887integral to plasma membraneCellular ComponentTAS (8264558)
GO:0030054cell junctionCellular ComponentIEA
GO:0031404chloride ion bindingMolecular FunctionIEA
GO:0030594neurotransmitter receptor activityMolecular FunctionIEA
GO:0004890GABA-A receptor activityMolecular FunctionTAS (8264558)
GO:0005254chloride channel activityMolecular FunctionIEA
GO:0005230extracellular ligand-gated ion channel activityMolecular FunctionIEA
GO:0005216ion channel activityMolecular FunctionIEA
GO:0007268synaptic transmissionBiological ProcessTAS (8264558)
GO:0006811ion transportBiological ProcessIEA
GO:0007214gamma-aminobutyric acid signaling pathwayBiological ProcessTAS (8264558)
Other Database Cross Links
NCBI Entrez Gene:2561
HGNC:4082
Ensembl:ENSG00000145864
MIM:600232
HPRD:02578
HuGE Navigator:2561
dbSNP:GABRB2
GeneCard:GABRB2
AceView:GABRB2