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Gene Information
Gene ID:31185
Organism:Drosophila melanogaster (Fly)
Genetic Location:2D4-2D4
Physical Location:2039168-2042598 on NC_004354.3
Gene Type:protein-coding
Human Ortholog:GeneID: 5226    Symbol (Name): PGD (phosphogluconate dehydrogenase)
Ortholog Status:The human GeneID 5226 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Pgd
P Value:4.27E-02
Note:Slow up-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_057512.3NP_476860.2NC_004354.3 range: 2039168..2042598
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activityMolecular FunctionIEA
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activityMolecular FunctionNAS
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activityMolecular FunctionTAS (1582561)
GO:0004672protein kinase activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0050661NADP bindingMolecular FunctionIEA
GO:0006098pentose-phosphate shuntBiological ProcessIEA
GO:0006098pentose-phosphate shuntBiological ProcessNAS
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:31185