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Gene Information
Gene ID:31201
Organism:Drosophila melanogaster (Fly)
Genetic Location:2E2-2E3
Physical Location:2108318-2116491 on NC_004354.3, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 7414    Symbol (Name): VCL (vinculin)
Ortholog Status:The human GeneID 7414 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Vinc
P Value:1.17E-02
Note:Slow up-regulation
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_057472.2NP_476820.1NC_004354.3 range: 2108318..2116491, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005925focal adhesionCellular ComponentISS (10908592)
GO:0015629actin cytoskeletonCellular ComponentIEA
GO:0003779actin bindingMolecular FunctionISS (10908588)
GO:0005198structural molecule activityMolecular FunctionIEA
GO:0006911phagocytosis, engulfmentBiological ProcessIMP (16336044)
GO:0007016cytoskeletal anchoringBiological ProcessISS (10908592)
GO:0007155cell adhesionBiological ProcessIEA
GO:0007155cell adhesionBiological ProcessNAS
Other Database Cross Links
NCBI Entrez Gene:31201