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Gene Information
Gene ID:31565
Alias:CG3458|TOP3|Topo IIIbeta|top3[beta]|topo III[beta]
Organism:Drosophila melanogaster (Fly)
Genetic Location:5E5-5E5
Physical Location:6178170-6181996 on NC_004354.3, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 8940    Symbol (Name): TOP3B (topoisomerase (DNA) III beta)
Ortholog Status:The human GeneID 8940 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Top3
P Value:3.76E-02
Note:Slow up-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_078504.2NP_511059.2NC_004354.3 range: 6178170..6181996, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0005694chromosomeCellular ComponentIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0004812aminoacyl-tRNA ligase activityMolecular FunctionIEA
GO:0004520endodeoxyribonuclease activityMolecular FunctionIDA (12023976)
GO:0003917DNA topoisomerase type I activityMolecular FunctionNAS
GO:0003917DNA topoisomerase type I activityMolecular FunctionISS
GO:0003916DNA topoisomerase activityMolecular FunctionNAS
GO:0003916DNA topoisomerase activityMolecular FunctionIDA (12023976)
GO:0006304DNA modificationBiological ProcessIEA
GO:0006268DNA unwinding during replicationBiological ProcessIEA
GO:0006265DNA topological changeBiological ProcessIEA
GO:0000737DNA catabolic process, endonucleolyticBiological ProcessIDA (12023976)
GO:0006418tRNA aminoacylation for protein translationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:31565