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Gene Information
Gene ID:326
Symbol:AIRE
Full Name:autoimmune regulator
Alias:AIRE1|APECED|APS1|APSI|PGA1
Organism:Homo sapiens (Human)
Chromosome:21
Genetic Location:21q22.3
Physical Location:44530190-44542529 on NC_000021.7
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AJ009610
Fold Change:-1.5, -1.6
Note:Differential Expression on the cDNA array (two fold changes are from two case groups)
Dataset Information
Name:11141048
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000383.2NP_000374.1NC_000021.7 range: 44530190..44542529
NM_000658.1NP_000649.1NC_000021.7 range: 44530190..44542529
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentNAS (9398840)
GO:0005737cytoplasmCellular ComponentIEA
GO:0003700transcription factor activityMolecular FunctionTAS (9398839)
GO:0045182translation regulator activityMolecular FunctionIEA
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0006959humoral immune responseBiological ProcessIEA
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessNAS (9398840)
Other Database Cross Links
NCBI Entrez Gene:326
HGNC:360
Ensembl:ENSG00000160224
MIM:607358
HPRD:06301
HuGE Navigator:326
dbSNP:AIRE
GeneCard:AIRE
AceView:AIRE