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Gene Information
Gene ID:33571
Symbol:tim
Alias:CG3234|Ritsu|dTIM|rit|tim1
Organism:Drosophila melanogaster (Fly)
Chromosome:2L
Genetic Location:23F6-23F6
Physical Location:3493985-3506740 on NT_033779.4, complement
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:tim
P Value:4.41E-02
Note:Transient down-regulation
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001014463.1NP_001014463.1NT_033779.4 range: 3493985..3506740, complement
NM_001038783.1NP_001033872.1NT_033779.4 range: 3493985..3506740, complement
NM_078744.3NP_523468.2NT_033779.4 range: 3493985..3506740, complement
NM_164540.2NP_722912.2NT_033779.4 range: 3493985..3506740, complement
NM_164541.3NP_722913.2NT_033779.4 range: 3493985..3506740, complement
NM_164542.3NP_722914.3NT_033779.4 range: 3493985..3506740, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIDA (12944510|16410523)
GO:0005737cytoplasmCellular ComponentTAS (12626480)
GO:0005737cytoplasmCellular ComponentNAS (12015613)
GO:0005634nucleusCellular ComponentIDA (12944510|16410523)
GO:0005634nucleusCellular ComponentNAS (12015613)
GO:0005634nucleusCellular ComponentTAS (12486701|12626480)
GO:0046982protein heterodimerization activityMolecular FunctionNAS (11178250)
GO:0005515protein bindingMolecular FunctionTAS (12626480)
GO:0046982protein heterodimerization activityMolecular FunctionTAS (15312644)
GO:0042306regulation of protein import into nucleusBiological ProcessTAS (11178250)
GO:0042749regulation of circadian sleep/wake cycleBiological ProcessIMP (16938867)
GO:0045187regulation of circadian sleep/wake cycle, sleepBiological ProcessIMP (12015603)
GO:0045187regulation of circadian sleep/wake cycle, sleepBiological ProcessTAS (12486704)
GO:0045475locomotor rhythmBiological ProcessIGI (17068124)
GO:0045475locomotor rhythmBiological ProcessNAS (11715043)
GO:0045475locomotor rhythmBiological ProcessTAS (12626480)
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessNAS (12015613)
GO:0030431sleepBiological ProcessNAS (11715043)
GO:0009649entrainment of circadian clockBiological ProcessTAS (11178250|12626480)
GO:0009648photoperiodismBiological ProcessIMP (17600215)
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessTAS (11178250)
GO:0006606protein import into nucleusBiological ProcessNAS (12015613)
GO:0007617mating behaviorBiological ProcessIMP (11470898)
GO:0007620copulationBiological ProcessIMP (15324667)
GO:0007622rhythmic behaviorBiological ProcessTAS (12486701)
GO:0007623circadian rhythmBiological ProcessNAS (11715043)
GO:0007623circadian rhythmBiological ProcessTAS (11178250|12015613|12154068|12490253|15312644)
GO:0008062eclosion rhythmBiological ProcessNAS (11715043)
GO:0008062eclosion rhythmBiological ProcessTAS (12111533|12486701|12626480)
GO:0048512circadian behaviorBiological ProcessIMP (11333398)
Other Database Cross Links
NCBI Entrez Gene:33571
FLYBASE:FBgn0014396