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Gene Information
Gene ID:3772247
Organism:Drosophila melanogaster (Fly)
Genetic Location:49B10-49B10
Physical Location:8521667-8523665 on NT_033778.3, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 4598    Symbol (Name): MVK (mevalonate kinase)
Ortholog Status:The human GeneID 4598 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG33671
P Value:1.35E-02
Note:Acute down-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001032241.1NP_001027412.1NT_033778.3 range: 8521667..8523665, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0004496mevalonate kinase activityMolecular FunctionISS
GO:0005524ATP bindingMolecular FunctionIEA
GO:0008299isoprenoid biosynthetic processBiological ProcessIEA
GO:0016310phosphorylationBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:3772247