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Gene Information
Gene ID:37729
Organism:Drosophila melanogaster (Fly)
Genetic Location:59E3-59E3
Physical Location:19438837-19441078 on NT_033778.3
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Dcp-1
P Value:1.26E-02
Note:Transient down-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_057626.3NP_476974.1NT_033778.3 range: 19438837..19441078
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0008303caspase complexCellular ComponentNAS
GO:0030693caspase activityMolecular FunctionIDA (8999799)
GO:0030693caspase activityMolecular FunctionISS (8999799)
GO:0030693caspase activityMolecular FunctionNAS (11048731)
GO:0030693caspase activityMolecular FunctionTAS (10511707|11139276|11178240|12072176|14644196)
GO:0035071salivary gland cell autophagic cell deathBiological ProcessIEP (12593804)
GO:0045476nurse cell apoptosisBiological ProcessTAS (11139280|12072176)
GO:0030036actin cytoskeleton organization and biogenesisBiological ProcessIMP (9422696)
GO:0009790embryonic developmentBiological ProcessIMP (8999799)
GO:0008632apoptotic programBiological ProcessIMP (9422696)
GO:0008632apoptotic programBiological ProcessIDA (8999799)
GO:0006508proteolysisBiological ProcessIEA
GO:0007303cytoplasmic transport, nurse cell to oocyteBiological ProcessTAS (11139276|11139280)
GO:0006508proteolysisBiological ProcessTAS (14644196)
GO:0006915apoptosisBiological ProcessIDA
GO:0006915apoptosisBiological ProcessNAS (11048731)
GO:0006915apoptosisBiological ProcessTAS (14644196)
GO:0006922cleavage of laminBiological ProcessIMP (9422696)
GO:0007015actin filament organizationBiological ProcessTAS (11139280)
GO:0007275multicellular organismal developmentBiological ProcessTAS (10511707)
GO:0007300ovarian nurse cell to oocyte transportBiological ProcessIMP (9422696)
GO:0007300ovarian nurse cell to oocyte transportBiological ProcessTAS (10511707)
GO:0048102autophagic cell deathBiological ProcessIEP (12593804)
Other Database Cross Links
NCBI Entrez Gene:37729