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Gene Information
Gene ID:42066
Organism:Drosophila melanogaster (Fly)
Genetic Location:89E12-89E13
Physical Location:12917256-12944862 on NT_033777.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 2316    Symbol (Name): FLNA (filamin A, alpha (actin binding protein 280))
Ortholog Status:The human GeneID 2316 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:cher
P Value:1.71E-02
Note:Slow up-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_079659.2NP_524383.3NT_033777.2 range: 12917256..12944862, complement
NM_169746.1NP_732207.1NT_033777.2 range: 12917256..12944862, complement
NM_169747.1NP_732208.1NT_033777.2 range: 12917256..12944862, complement
NM_206502.1NP_996224.1NT_033777.2 range: 12917256..12944862, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0035183germline ring canal inner rimCellular ComponentIDA (10556087)
GO:0035182germline ring canal outer rimCellular ComponentIDA (10556087)
GO:0003779actin bindingMolecular FunctionISS (10556087|10908588)
GO:0030725ring canal formationBiological ProcessIMP (12885568)
GO:0030708germarium-derived female germ-line cyst encapsulationBiological ProcessIMP (12885568)
GO:0008355olfactory learningBiological ProcessIMP (12593794)
GO:0008340determination of adult life spanBiological ProcessIMP (12620118)
GO:0008302ring canal formation, actin assemblyBiological ProcessIMP (10556087)
GO:0008104protein localizationBiological ProcessIMP (9093858)
GO:0007611learning and/or memoryBiological ProcessIMP (12593794)
GO:0007301ovarian ring canal formationBiological ProcessIMP (9093858)
GO:0035204negative regulation of lamellocyte differentiationBiological ProcessIMP (16616709)
Other Database Cross Links
NCBI Entrez Gene:42066