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Gene Information
Gene ID:43383
Organism:Drosophila melanogaster (Fly)
Genetic Location:98D5-98D5
Physical Location:24407537-24410804 on NT_033777.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 3170    Symbol (Name): FOXA2 (forkhead box A2)
Ortholog Status:The human GeneID 3170 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:fkh
P Value:4.01E-03
Note:Slow up-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_079818.2NP_524542.1NT_033777.2 range: 24407537..24410804, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentISS
GO:0005634nucleusCellular ComponentNAS
GO:0043565sequence-specific DNA bindingMolecular FunctionIEA
GO:0030528transcription regulator activityMolecular FunctionNAS
GO:0003700transcription factor activityMolecular FunctionISS
GO:0007435salivary gland morphogenesisBiological ProcessIMP (10976053)
GO:0007435salivary gland morphogenesisBiological ProcessTAS (11598957|12742168)
GO:0007439ectodermal gut developmentBiological ProcessTAS (10512197)
GO:0007443Malpighian tubule morphogenesisBiological ProcessTAS (10512197)
GO:0007432salivary gland boundary specificationBiological ProcessNAS
GO:0007431salivary gland developmentBiological ProcessNAS (14624839)
GO:0007431salivary gland developmentBiological ProcessIMP (15901661)
GO:0006916anti-apoptosisBiological ProcessTAS (12742168)
GO:0006916anti-apoptosisBiological ProcessIMP (10976053)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessNAS
GO:0006355regulation of transcription, DNA-dependentBiological ProcessISS
GO:0001706endoderm formationBiological ProcessTAS (11959838)
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessTAS (11598957)
Other Database Cross Links
NCBI Entrez Gene:43383