Home Search BLAST Integration Document Link Support Citation Quick Search (e.g. 124 or ADH*)

Gene Information
Gene ID:50096
Symbol:Spase12
Alias:CG11500|CG31042
Organism:Drosophila melanogaster (Fly)
Chromosome:3R
Genetic Location:99B1-99B1
Physical Location:25316264-25316815 on NT_033777.2, complement
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG11500
P Value:3.48E-02
Note:Slow down-regulation
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_176583.1NP_788760.1NT_033777.2 range: 25316264..25316815, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005787signal peptidase complexCellular ComponentIEA
GO:0005787signal peptidase complexCellular ComponentNAS
GO:0005792microsomeCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0009003signal peptidase activityMolecular FunctionIEA
GO:0009003signal peptidase activityMolecular FunctionNAS
GO:0006465signal peptide processingBiological ProcessIEA
GO:0006465signal peptide processingBiological ProcessNAS
Other Database Cross Links
NCBI Entrez Gene:50096
FLYBASE:FBgn0040623