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Gene Information
Gene ID:51195
Symbol:RAPGEFL1
Full Name:Rap guanine nucleotide exchange factor (GEF)-like 1
Alias:Link-GEFII|MGC134798|MGC134799
Organism:Homo sapiens (Human)
Chromosome:17
Genetic Location:17q21.1-q21.2
Physical Location:35591393-35605425 on NC_000017.9
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AA707689
Fold Change:1.5, 1.7
Note:Differential Expression on the cDNA array (two fold changes are from two case groups)
Dataset Information
Name:11141048
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_016339.3NP_057423.1NC_000017.9 range: 35591393..35605425
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005622intracellularCellular ComponentIEA
GO:0005624membrane fractionCellular ComponentTAS (9582122)
GO:0005085guanyl-nucleotide exchange factor activityMolecular FunctionTAS (9582122)
GO:0007165signal transductionBiological ProcessIEA
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessTAS (9582122)
GO:0007264small GTPase mediated signal transductionBiological ProcessIEA
GO:0007399nervous system developmentBiological ProcessTAS (9789079)
Other Database Cross Links
NCBI Entrez Gene:51195
HGNC:17428
Ensembl:ENSG00000108352
MIM:
HPRD:17954
HuGE Navigator:51195
dbSNP:RAPGEFL1
GeneCard:RAPGEFL1
AceView:RAPGEFL1