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Gene Information
Gene ID:51330
Symbol:TNFRSF12A
Full Name:tumor necrosis factor receptor superfamily, member 12A
Alias:CD266|FN14|TWEAKR
Organism:Homo sapiens (Human)
Chromosome:16
Genetic Location:16p13.3
Physical Location:3010360-3012384 on NC_000016.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AI827127
Fold Change:1.8, 1.4
Note:Differential Expression on the cDNA array (two fold changes are from two case groups)
Dataset Information
Name:11141048
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_016639.2NP_057723.1NC_000016.8 range: 3010360..3012384
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0004872receptor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0001525angiogenesisBiological ProcessIEA
GO:0007275multicellular organismal developmentBiological ProcessTAS (10551889)
GO:0007155cell adhesionBiological ProcessIEA
GO:0006928cell motilityBiological ProcessTAS (10551889)
GO:0006915apoptosisBiological ProcessIEA
GO:0030154cell differentiationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:51330
HGNC:18152
Ensembl:ENSG00000006327
MIM:605914
HPRD:05801
HuGE Navigator:51330
dbSNP:TNFRSF12A
GeneCard:TNFRSF12A
AceView:TNFRSF12A