Gene Page: CHRM1

Summary
GeneID  1128
Symbol  CHRM1
Synonyms  HM1|M1|MGC30125
Description  cholinergic receptor, muscarinic 1
See related  HGNC:1950|MIM:118510|Ensembl:ENSG00000168539|HPRD:00338|
Locus tag  -
Gene type  protein-coding
Map location  11q13
 
Gene in Data Sources
Gene set nameMethod of gene setEvidenceInfo
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
Gene Expression ?
 
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004435phosphoinositide phospholipase C activityTAS9614217 
GO:0004872receptor activityIEA-
GO:0004981muscarinic acetylcholine receptor activityTAS9614217 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006464protein modification processTAS1411529 
GO:0007165signal transductionTAS3443095 |9614217 
GO:0007205activation of protein kinase C activityTAS9603968 
GO:0007207muscarinic acetylcholine receptor, phospholipase C activating pathwayTAS8139539 
GO:0007213acetylcholine receptor signaling, muscarinic pathwayTAS8139539 
GO:0007399nervous system developmentTASneurite (GO term level: 5)2739737 
GO:0008284positive regulation of cell proliferationTAS2739737 
GO:0040012regulation of locomotionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005624membrane fractionTAS7925360 
GO:0005886plasma membraneTAS7925360 
GO:0005887integral to plasma membraneTAS8508928 
GO:0030054cell junctionIEA-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GNAI2GIP | GNAI2B | H_LUCA15.1 | H_LUCA16.1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2-HPRD,BioGRID8190105 
GPRASP1GASP | GASP1 | KIAA0443G protein-coupled receptor associated sorting protein 1GASP-1 interacts with M1.BIND15086532 
GPRASP2FLJ35662 | FLJ37327 | GASP2G protein-coupled receptor associated sorting protein 2GASP-2 interacts with M1.BIND15086532 
 
KEGG Pathway Info
hsa04020: Calcium signaling pathway - Homo sapiens (human)Go to KEGGAll SZGR genes in this pathway
hsa04080: Neuroactive ligand-receptor interaction - Homo sapiens (human)Go to KEGGAll SZGR genes in this pathway
hsa04810: Regulation of actin cytoskeleton - Homo sapiens (human)Go to KEGGAll SZGR genes in this pathway
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/107845851m8hsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-27101010161Ahsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-4918678731Ahsa-miR-491brainAGUGGGGAACCCUUCCAUGAGGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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