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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: MAP3K8

Summary

GeneID

1326

Symbol

MAP3K8

Synonyms

COT|EST|ESTF|FLJ10486|TPL2|Tpl-2|c-COT

Description

mitogen-activated protein kinase kinase kinase 8

Locus tag

RP11-449I17.8

Gene type

protein-coding

Map location

10p11.23

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0333

Gene Expression ?

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0000287

magnesium ion binding

IEA

GO:0004672

protein kinase activity

IEA

GO:0004674

protein serine/threonine kinase activity

TAS

8226782

GO:0004709

MAP kinase kinase kinase activity

IEA

GO:0005515

protein binding

IEA

GO:0005515

protein binding

IPI

15169888

GO:0005524

ATP binding

IEA

GO:0016740

transferase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006468

protein amino acid phosphorylation

IEA

GO:0006468

protein amino acid phosphorylation

TAS

2072910

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005737

cytoplasm

IEA

GO:0005829

cytosol

TAS

8226782

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AKT1	AKT \| MGC99656 \| PKB \| PKB-ALPHA \| PRKBA \| RAC \| RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1	-	HPRD,BioGRID	12138205
CHUK	IKBKA \| IKK-alpha \| IKK1 \| IKKA \| NFKBIKA \| TCF16	conserved helix-loop-helix ubiquitous kinase	-	HPRD,BioGRID	10072079
KSR2	FLJ25965	kinase suppressor of ras 2	Affinity Capture-Western	BioGRID	12975377
MAP2K1	MAPKK1 \| MEK1 \| MKK1 \| PRKMK1	mitogen-activated protein kinase kinase 1	Biochemical Activity	BioGRID	8631303
MAP2K4	JNKK \| JNKK1 \| MAPKK4 \| MEK4 \| MKK4 \| PRKMK4 \| SEK1 \| SERK1	mitogen-activated protein kinase kinase 4	-	HPRD,BioGRID	8631303
MAP3K14	FTDCR1B \| HS \| HSNIK \| NIK	mitogen-activated protein kinase kinase kinase 14	-	HPRD,BioGRID	10072079
NFKB1	DKFZp686C01211 \| EBP-1 \| KBF1 \| MGC54151 \| NF-kappa-B \| NFKB-p105 \| NFKB-p50 \| p105	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	-	HPRD,BioGRID	9950430
NFKB2	LYT-10 \| LYT10	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	Affinity Capture-MS	BioGRID	14743216
REL	C-Rel	v-rel reticuloendotheliosis viral oncogene homolog (avian)	Affinity Capture-MS	BioGRID	14743216
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Affinity Capture-MS	BioGRID	14743216
TNIP2	ABIN-2 \| ABIN2 \| FLIP1 \| KLIP \| MGC4289	TNFAIP3 interacting protein 2	-	HPRD,BioGRID	14743216 \|15169888
TRAF2	MGC:45012 \| TRAP \| TRAP3	TNF receptor-associated factor 2	-	HPRD,BioGRID	11932422

KEGG Pathway Info

hsa04010: MAPK signaling pathway - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa04620: Toll-like receptor signaling pathway - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa04660: T cell receptor signaling pathway - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-140	680	687	1A,m8	hsa-miR-140^brain	AGUGGUUUUACCCUAUGGUAG
miR-146	199	205	1A	hsa-miR-146a	UGAGAACUGAAUUCCAUGGGUU
miR-146	199	205	1A	hsa-miR-146b^brain	UGAGAACUGAAUUCCAUAGGCU
miR-17-5p/20/93.mr/106/519.d	286	292	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-299-3p	683	689	1A	hsa-miR-299-3p	UAUGUGGGAUGGUAAACCGCUU
miR-299-5p	678	685	1A,m8	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-370	567	573	m8	hsa-miR-370^brain	GCCUGCUGGGGUGGAACCUGG
miR-539	205	212	1A,m8	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.