Gene Page

Gene Page: GNAZ

Summary

GeneID

2781

Symbol

GNAZ

Synonyms

Description

guanine nucleotide binding protein (G protein), alpha z polypeptide

Locus tag

Gene type

protein-coding

Map location

22q11.22

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.031

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.2005

Gene Expression ?

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0003924

GTPase activity

TAS

2117645

GO:0005057

receptor signaling protein activity

TAS

2456569

GO:0005525

GTP binding

IEA

GO:0019001

guanyl nucleotide binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007165

signal transduction

IEA

GO:0007186

G-protein coupled receptor protein signaling pathway

TAS

3129724

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005635

nuclear envelope

TAS

2117645

GO:0005737

cytoplasm

IDA

18029348

GO:0005783

endoplasmic reticulum

TAS

2117645

GO:0005886

plasma membrane

TAS

3129724

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
DRD2	D2DR \| D2R	dopamine receptor D2	-	HPRD	9166747
DRD5	DBDR \| DRD1B \| DRD1L2 \| MGC10601	dopamine receptor D5	-	HPRD	9603210
EYA2	EAB1 \| MGC10614	eyes absent homolog 2 (Drosophila)	-	HPRD,BioGRID	10906137
OPRD1	OPRD	opioid receptor, delta 1	-	HPRD	9166747
RAP1GAP	KIAA0474 \| RAP1GA1 \| Rap1GAP1 \| rap1GAPII	RAP1 GTPase activating protein	-	HPRD,BioGRID	10593970
RGS10	-	regulator of G-protein signaling 10	Affinity Capture-Western	BioGRID	8774883
RGS19	GAIP \| RGSGAIP	regulator of G-protein signaling 19	-	HPRD,BioGRID	8986788
RGS20	RGSZ1 \| ZGAP1	regulator of G-protein signaling 20	-	HPRD	9748279\|12414994
RGS20	RGSZ1 \| ZGAP1	regulator of G-protein signaling 20	Biochemical Activity Co-localization	BioGRID	9748279 \|12414994
RGS7	-	regulator of G-protein signaling 7	-	HPRD,BioGRID	10092682

KEGG Pathway Info

hsa04730: Long-term depression - Homo sapiens (human)

Go to KEGG

All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-129-5p	637	643	m8	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	637	643	m8	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-186	858	864	m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-27	1260	1266	1A	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	1260	1266	1A	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-331	80	86	m8	hsa-miR-331^brain	GCCCCUGGGCCUAUCCUAGAA
miR-450	637	643	1A	hsa-miR-450	UUUUUGCGAUGUGUUCCUAAUA
miR-452	153	160	1A,m8	hsa-miR-452	UGUUUGCAGAGGAAACUGAGAC
miR-542-3p	273	280	1A,m8	hsa-miR-542-3p	UGUGACAGAUUGAUAACUGAAA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.