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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: IGFBP3

Summary

GeneID

3486

Symbol

IGFBP3

Synonyms

BP-53|IBP3

Description

insulin-like growth factor binding protein 3

See related

HGNC:5472|MIM:146732|Ensembl:ENSG00000146674|HPRD:00899|

Locus tag

tcag7.703

Gene type

protein-coding

Map location

7p13-p12

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

Gene Expression ?

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

insulin-like growth factor binding

IEA

-

protein tyrosine phosphatase activator activity

IDA

insulin-like growth factor I binding

IPI

metal ion binding

NAS

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

regulation of cell growth

IEA

-

negative regulation of protein amino acid phosphorylation

IDA

negative regulation of signal transduction

NAS

negative regulation of smooth muscle cell migration

IDA

positive regulation of apoptosis

IMP

positive regulation of myoblast differentiation

IDA

negative regulation of smooth muscle cell proliferation

IDA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

extracellular region

IEA

-

extracellular region

NAS

extracellular space

IEA

-

nucleus

IDA

insulin-like growth factor binding protein complex

IC

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ADAM12	MCMP \| MCMPMltna \| MLTN \| MLTNA	ADAM metallopeptidase domain 12	-	HPRD,BioGRID	10849447
CD44	CDW44 \| CSPG8 \| ECMR-III \| HCELL \| IN \| LHR \| MC56 \| MDU2 \| MDU3 \| MGC10468 \| MIC4 \| MUTCH-I \| Pgp1	CD44 molecule (Indian blood group)	-	HPRD,BioGRID	12127836
COL1A1	OI4	collagen, type I, alpha 1	-	HPRD,BioGRID	12735930
FN1	CIG \| DKFZp686F10164 \| DKFZp686H0342 \| DKFZp686I1370 \| DKFZp686O13149 \| ED-B \| FINC \| FN \| FNZ \| GFND \| GFND2 \| LETS \| MSF	fibronectin 1	-	HPRD,BioGRID	11344214
GTF3C1	DKFZp686A111 \| TFIIIC \| TFIIIC220 \| TFIIICalpha	general transcription factor IIIC, polypeptide 1, alpha 220kDa	Two-hybrid	BioGRID	16169070
IGF1	IGFI	insulin-like growth factor 1 (somatomedin C)	-	HPRD,BioGRID	11600567
IGF1	IGFI	insulin-like growth factor 1 (somatomedin C)	IGF-I interacts with IGFBP-3.	BIND	10407151
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	-	HPRD,BioGRID	9389554
IGF2	C11orf43 \| FLJ22066 \| FLJ44734 \| INSIGF \| pp9974	insulin-like growth factor 2 (somatomedin A)	Reconstituted Complex	BioGRID	11600567 \|11749962
IGF2	C11orf43 \| FLJ22066 \| FLJ44734 \| INSIGF \| pp9974	insulin-like growth factor 2 (somatomedin A)	IGF-II interacts with IGFBP-3.	BIND	10407151
IGFALS	ALS	insulin-like growth factor binding protein, acid labile subunit	-	HPRD,BioGRID	9446566 \|9497324
KLK3	APS \| KLK2A1 \| PSA \| hK3	kallikrein-related peptidase 3	-	HPRD,BioGRID	1383255 \|10511594
KLKB1	KLK3 \| PPK	kallikrein B, plasma (Fletcher factor) 1	-	HPRD	10226805
LTBP1	MGC163161	latent transforming growth factor beta binding protein 1	-	HPRD	12962157
PAPPA2	PAPP-A2 \| PAPPE \| PLAC3	pappalysin 2	-	HPRD,BioGRID	11264294
PLG	DKFZp779M0222	plasminogen	-	HPRD,BioGRID	9688635
POLA2	FLJ21662 \| FLJ37250	polymerase (DNA directed), alpha 2 (70kD subunit)	Two-hybrid	BioGRID	16169070
RXRA	FLJ00280 \| FLJ00318 \| FLJ16020 \| FLJ16733 \| MGC102720 \| NR2B1	retinoid X receptor, alpha	-	HPRD,BioGRID	10874028
TF	DKFZp781D0156 \| PRO1557 \| PRO2086	transferrin	-	HPRD,BioGRID	11297622 \|11749962

KEGG Pathway Info

hsa04115: p53 signaling pathway - Homo sapiens (human)

All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-19	43	50	1A,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	43	50	1A,m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-34/449	55	61	1A	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-381	1122	1128	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

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