Gene Page: MSH2

Summary
GeneID  4436
Symbol  MSH2
Synonyms  COCA1|FCC1|HNPCC|HNPCC1|LCFS2
Description  mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
See related  HGNC:7325|MIM:609309|Ensembl:ENSG00000095002|HPRD:00389|
Locus tag  -
Gene type  protein-coding
Map location  2p22-p21
 
Gene in Data Sources
Gene set nameMethod of gene setEvidenceInfo
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
Gene Expression ?
 
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIDA16403449 
GO:0000400four-way junction DNA bindingIDA12034830 
GO:0003677DNA bindingIDA7923193 
GO:0003684damaged DNA bindingIEA-
GO:0003697single-stranded DNA bindingIDA11809883 
GO:0004422hypoxanthine phosphoribosyltransferase activityIEA-
GO:0005524ATP bindingIDA15105434 
GO:0005524ATP bindingIEA-
GO:0008022protein C-terminus bindingIPI14706347 
GO:0016887ATPase activityIDA16403449 
GO:0016887ATPase activityIEA-
GO:0019237centromeric DNA bindingIEA-
GO:0030983mismatched DNA bindingIEA-
GO:0032137guanine/thymine mispair bindingIDA8942985 |11809883 
GO:0032137guanine/thymine mispair bindingIEA-
GO:0032142single guanine insertion bindingIDA8942985 
GO:0032143single thymine insertion bindingIDA8942985 
GO:0032181dinucleotide repeat insertion bindingIDA8942985 
GO:0032357oxidized purine DNA bindingIDA11756455 |11801590 
GO:0032405MutLalpha complex bindingIDA16403449 
GO:0042803protein homodimerization activityIDA8942985 
GO:0043531ADP bindingIDA15105434 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001701in utero embryonic developmentIEA-
GO:0006119oxidative phosphorylationIEA-
GO:0006164purine nucleotide biosynthetic processIEA-
GO:0006284base-excision repairIDA8942985 
GO:0006298mismatch repairIDA7923193 
GO:0006298mismatch repairIEA-
GO:0006301postreplication repairIDA7923193 
GO:0006915apoptosisIEA-
GO:0006928cell motionIEA-
GO:0007050cell cycle arrestIEA-
GO:0008340determination of adult life spanIEA-
GO:0008584male gonad developmentISS-
GO:0010165response to X-rayIEA-
GO:0010165response to X-rayISS-
GO:0010224response to UV-BIEA-
GO:0010224response to UV-BISS-
GO:0016446somatic hypermutation of immunoglobulin genesIEA-
GO:0016447somatic recombination of immunoglobulin gene segmentsISS-
GO:0019724B cell mediated immunityIEA-
GO:0019724B cell mediated immunityISS-
GO:0030183B cell differentiationIEA-
GO:0030183B cell differentiationISS-
GO:0031573intra-S DNA damage checkpointIEA-
GO:0043524negative regulation of neuron apoptosisIEAneuron (GO term level: 9)-
GO:0043524negative regulation of neuron apoptosisISSneuron (GO term level: 9)-
GO:0043570maintenance of DNA repeat elementsIMP16388310 
GO:0045190isotype switchingIEA-
GO:0045190isotype switchingISS-
GO:0045786negative regulation of cell cycleIEA-
GO:0045910negative regulation of DNA recombinationIEA-
GO:0045910negative regulation of DNA recombinationISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0032301MutSalpha complexIDA8942985 
GO:0032301MutSalpha complexIEA-
GO:0032302MutSbeta complexIDA8942985 
GO:0032302MutSbeta complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATMAT1 | ATA | ATC | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 | TELO1ataxia telangiectasia mutatedCo-purificationBioGRID10783165 
ATRFRP1 | MEC1 | SCKL | SCKL1ataxia telangiectasia and Rad3 related-HPRD,BioGRID14657349 
ATRIPDKFZp762J2115 | FLJ12343 | MGC20625 | MGC21482 | MGC26740ATR interacting proteinAffinity Capture-WesternBioGRID14657349 
BARD1-BRCA1 associated RING domain 1-HPRD,BioGRID11498787 
BLMBS | MGC126616 | MGC131618 | MGC131620 | RECQ2 | RECQL2 | RECQL3Bloom syndromeCo-purificationBioGRID10783165 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD,BioGRID11498787 
BRCA1 interacts with MSH2 in the absence of ADP-MSH2 interaction.BIND10783165 
CHEK1CHK1CHK1 checkpoint homolog (S. pombe)Affinity Capture-WesternBioGRID15647386 
CHEK2CDS1 | CHK2 | HuCds1 | LFS2 | PP1425 | RAD53CHK2 checkpoint homolog (S. pombe)-HPRD,BioGRID12447371 
E2F1E2F-1 | RBAP1 | RBBP3 | RBP3E2F transcription factor 1E2F1 interacts with the MSH2 promoter.BIND11799067 
The 5'MSH2 promoter region interacts with E2F1.BIND15619620 
E2F3DKFZp686C18211 | E2F-3 | KIAA0075 | MGC104598E2F transcription factor 3E2F3 interacts with the MSH2 promoter.BIND11799067 
E2F4E2F-4E2F transcription factor 4, p107/p130-bindingE2F4 interacts with the MSH2 promoter.BIND11799067 
EXO1HEX1 | hExoIexonuclease 1The exonuclease hEXO1b interacts with the mismatch repair protein hMSH2.BIND11429708 
The exonuclease HEX1 interacts with the mismatch repair protein hMSH2.BIND11429708 
-HPRD,BioGRID9788596 |10856833 
MAXMGC10775 | MGC11225 | MGC18164 | MGC34679 | MGC36767 | bHLHd4 | orf1MYC associated factor X-HPRD,BioGRID12584560 
Max interacts with MSH2. This is a modeled interaction between Max from an unspecified source and human MSH2.BIND12584560 
MLH1COCA2 | FCC2 | HNPCC | HNPCC2 | MGC5172 | hMLH1mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)Co-purificationBioGRID10783165 
MRE11AATLD | HNGS1 | MRE11 | MRE11BMRE11 meiotic recombination 11 homolog A (S. cerevisiae)Co-purificationBioGRID10783165 
MSH3DUP | MGC163306 | MGC163308 | MRP1mutS homolog 3 (E. coli)MSH2/HNPCC interacts with MSH3BIND9774676 
-HPRD,BioGRID8942985 |9774676 
MSH6GTBP | HNPCC5 | HSAPmutS homolog 6 (E. coli)MSH2 interacts with MSH6.BIND15753043 
MSH2 interacts with MSH6.BIND9428522 
-HPRD,BioGRID8942985 |9774676 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Affinity Capture-WesternBioGRID12584560 
NBNAT-V1 | AT-V2 | ATV | FLJ10155 | MGC87362 | NBS | NBS1 | P95nibrinCo-purificationBioGRID10783165 
PCNAMGC8367proliferating cell nuclear antigen-HPRD,BioGRID8858149 |12171929 
PTP4A3PRL-3 | PRL-R | PRL3protein tyrosine phosphatase type IVA, member 3Affinity Capture-MSBioGRID17353931 
RAD50RAD50-2 | hRad50RAD50 homolog (S. cerevisiae)Co-purificationBioGRID10783165 
RFC1A1 | MGC51786 | MHCBFB | PO-GA | RECC1 | RFC | RFC140replication factor C (activator 1) 1, 145kDaCo-purificationBioGRID10783165 
SMC1ACDLS2 | DKFZp686L19178 | DXS423E | KIAA0178 | MGC138332 | SB1.8 | SMC1 | SMC1L1 | SMC1alpha | SMCBstructural maintenance of chromosomes 1A-HPRD14657349 
 
KEGG Pathway Info
hsa03430: Mismatch repair - Homo sapiens (human)Go to KEGGAll SZGR genes in this pathway
hsa05210: Colorectal cancer - Homo sapiens (human)Go to KEGGAll SZGR genes in this pathway
 


Copyright © Bioinformatics Lab @ VIPBG, VCU All Rights Reserved.