Gene Page: MSH3

Summary
GeneID  4437
Symbol  MSH3
Synonyms  DUP|MGC163306|MGC163308|MRP1
Description  mutS homolog 3 (E. coli)
See related  HGNC:7326|MIM:600887|Ensembl:ENSG00000113318|HPRD:02931|
Locus tag  -
Gene type  protein-coding
Map location  5q11-q12
 
Gene in Data Sources
Gene set nameMethod of gene setEvidenceInfo
ExpressionExpressionP value: 1.688 
 
Gene Expression ?
 
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000701purine-specific mismatch base pair DNA N-glycosylase activityIMP11005803 
GO:0003684damaged DNA bindingIEA-
GO:0003697single-stranded DNA bindingIDA11809883 
GO:0005515protein bindingIPI11427529 |14657349 
GO:0005524ATP bindingIEA-
GO:0019237centromeric DNA bindingIEA-
GO:0030983mismatched DNA bindingIDA8942985 
GO:0032137guanine/thymine mispair bindingIDA11809883 
GO:0032142single guanine insertion bindingIDA8942985 
GO:0032181dinucleotide repeat insertion bindingIDA8942985 
GO:0032357oxidized purine DNA bindingIDA11756455 
GO:0042803protein homodimerization activityIDA8942985 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006284base-excision repairIDA8942985 
GO:0006298mismatch repairIDA11005803 
GO:0006298mismatch repairIMP8782829 
GO:0016447somatic recombination of immunoglobulin gene segmentsIEA-
GO:0043570maintenance of DNA repeat elementsIMP16388310 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0032302MutSbeta complexIDA8942985 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BARD1-BRCA1 associated RING domain 1Reconstituted ComplexBioGRID11498787 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetProtein-peptide
Reconstituted Complex
BioGRID11498787 |14578343 
EXO1HEX1 | hExoIexonuclease 1-HPRD,BioGRID11427529 
MSH3 interacts with human exonuclease I.BIND11427529 
MSH2COCA1 | FCC1 | HNPCC | HNPCC1 | LCFS2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)MSH2/HNPCC interacts with MSH3BIND9774676 
-HPRD,BioGRID8942985 |9774676 
PCNAMGC8367proliferating cell nuclear antigenMSH3 is a PCNA-binding proteinBIND12171929 
-HPRD,BioGRID11005803 |11274057 
|12171929 
 
KEGG Pathway Info
hsa03430: Mismatch repair - Homo sapiens (human)Go to KEGGAll SZGR genes in this pathway
hsa05210: Colorectal cancer - Homo sapiens (human)Go to KEGGAll SZGR genes in this pathway
 


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