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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: NRAS

Summary

GeneID

4893

Symbol

NRAS

Synonyms

ALPS4|N-ras|NRAS1

Description

neuroblastoma RAS viral (v-ras) oncogene homolog

Locus tag

Gene type

protein-coding

Map location

1p13.2

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.0235

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.00814

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 3

Gene Expression ?

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0003924

GTPase activity

IEA

GO:0005515

protein binding

IEA

GO:0005525

GTP binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006897

endocytosis

IEA

GO:0007265

Ras protein signal transduction

EXP

11520933

GO:0007265

Ras protein signal transduction

IEA

GO:0007569

cell aging

IEA

GO:0008284

positive regulation of cell proliferation

IEA

GO:0008542

visual learning

IEA

GO:0030036

actin cytoskeleton organization

IEA

GO:0032228

regulation of synaptic transmission, GABAergic

IEA

neuron, GABA, Synap, Neurotransmitter (GO term level: 9)

GO:0035022

positive regulation of Rac protein signal transduction

IEA

GO:0043524

negative regulation of neuron apoptosis

IEA

neuron (GO term level: 9)

GO:0048169

regulation of long-term neuronal synaptic plasticity

IEA

neuron, Synap (GO term level: 10)

GO:0051146

striated muscle cell differentiation

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000139

Golgi membrane

IEA

GO:0005622

intracellular

IEA

GO:0005624

membrane fraction

IEA

GO:0005794

Golgi apparatus

IEA

GO:0005886

plasma membrane

EXP

7972015 |8493579 |9069260
|9690470

GO:0005886

plasma membrane

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ARHGAP4	C1 \| KIAA0131 \| RGC1 \| RhoGAP4 \| p115	Rho GTPase activating protein 4	-	HPRD	10655059
BCL2	Bcl-2	B-cell CLL/lymphoma 2	-	HPRD	10490827
MLLT4	AF-6 \| AF6 \| AFADIN \| FLJ34371 \| RP3-431P23.3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	Affinity Capture-Western	BioGRID	12808105
PIK3CG	PI3CG \| PI3K \| PI3Kgamma \| PIK3	phosphoinositide-3-kinase, catalytic, gamma polypeptide	Reconstituted Complex	BioGRID	11136978
PLCE1	FLJ23659 \| KIAA1516 \| MGC167842 \| NPHS3 \| PLCE	phospholipase C, epsilon 1	Two-hybrid	BioGRID	16169070
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	Nras interacts with Raf. This interaction was modelled on a demonstrated interaction between Nras and Raf, both from an unspecified species.	BIND	15705808
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	Affinity Capture-Western	BioGRID	10882715
RAP1GDS1	GDS1 \| MGC118859 \| MGC118861 \| SmgGDS	RAP1, GTP-GDP dissociation stimulator 1	-	HPRD,BioGRID	11948427
RASGRP2	CALDAG-GEFI \| CDC25L	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	-	HPRD	10918068
SHOC2	FLJ60412 \| KIAA0862 \| SIAA0862 \| SOC-2 \| SOC2 \| SUR-8 \| SUR8	soc-2 suppressor of clear homolog (C. elegans)	-	HPRD	9674433

KEGG Pathway Info

hsa04010: MAPK signaling pathway - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa04012: ErbB signaling pathway - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa04360: Axon guidance - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa04370: VEGF signaling pathway - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa04530: Tight junction - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa04540: Gap junction - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa04650: Natural killer cell mediated cytotoxicity - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa04660: T cell receptor signaling pathway - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa04662: B cell receptor signaling pathway - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa04664: Fc epsilon RI signaling pathway - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa04720: Long-term potentiation - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa04730: Long-term depression - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa04810: Regulation of actin cytoskeleton - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa04910: Insulin signaling pathway - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa04912: GnRH signaling pathway - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa04916: Melanogenesis - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa05211: Renal cell carcinoma - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa05213: Endometrial cancer - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa05214: Glioma - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa05215: Prostate cancer - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa05216: Thyroid cancer - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa05218: Melanoma - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa05219: Bladder cancer - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa05220: Chronic myeloid leukemia - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa05221: Acute myeloid leukemia - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway
hsa05223: Non-small cell lung cancer - Homo sapiens (human)	Go to KEGG	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	186	192	m8	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-124/506	640	646	m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	640	646	m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-196	185	191	m8	hsa-miR-196a	UAGGUAGUUUCAUGUUGUUGG
miR-196	185	191	m8	hsa-miR-196b	UAGGUAGUUUCCUGUUGUUGG
miR-28	116	122	m8	hsa-miR-28^brain	AAGGAGCUCACAGUCUAUUGAG
miR-326	210	216	1A	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-361	966	972	1A	hsa-miR-361^brain	UUAUCAGAAUCUCCAGGGGUAC
miR-505	418	424	1A	hsa-miR-505	GUCAACACUUGCUGGUUUCCUC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.