Gene Page: POLD1

Summary
GeneID  5424
Symbol  POLD1
Synonyms  CDC2|POLD
Description  polymerase (DNA directed), delta 1, catalytic subunit 125kDa
See related  HGNC:9175|MIM:174761|Ensembl:ENSG00000062822|HPRD:08882|
Locus tag  -
Gene type  protein-coding
Map location  19q13.3
 
Gene in Data Sources
Gene set nameMethod of gene setEvidenceInfo
ExpressionExpressionP value: 1.401 
 
Gene Expression ?
 
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003677DNA bindingIDA16762037 
GO:0003677DNA bindingIEA-
GO:0003682chromatin bindingIDA16762037 
GO:0003887DNA-directed DNA polymerase activityIEA-
GO:0003887DNA-directed DNA polymerase activityIMP16762037 
GO:0004527exonuclease activityIEA-
GO:0005515protein bindingIPI15670210 
GO:0008270zinc ion bindingIEA-
GO:00084083'-5' exonuclease activityIEA-
GO:0016740transferase activityIEA-
GO:0016779nucleotidyltransferase activityIEA-
GO:0016787hydrolase activityIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000084S phase of mitotic cell cycleIDA16762037 
GO:0000731DNA synthesis during DNA repairIDA3335506 
GO:0000731DNA synthesis during DNA repairIMP1730053 
GO:0006139nucleobase, nucleoside, nucleotide and nucleic acid metabolic processIEA-
GO:0006260DNA replicationIEA-
GO:0006287base-excision repair, gap-fillingIEA-
GO:0006297nucleotide-excision repair, DNA gap fillingEXP9111189 
GO:0009411response to UVTAS3146346 
GO:0045004DNA replication proofreadingIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA16762037 
GO:0005634nucleusIEA-
GO:0005654nucleoplasmEXP10559261 |11473323 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATRFRP1 | MEC1 | SCKL | SCKL1ataxia telangiectasia and Rad3 relatedProtein-peptideBioGRID10608806 
CHGBSCG1chromogranin B (secretogranin 1)Two-hybridBioGRID16169070 
KIAA1377-KIAA1377Two-hybridBioGRID16169070 
PCNAMGC8367proliferating cell nuclear antigenPOLD1 is a PCNA-binding proteinBIND12171929 
-HPRD,BioGRID9563011 
POLA1DKFZp686K1672 | POLA | p180polymerase (DNA directed), alpha 1, catalytic subunit-HPRD,BioGRID9563011 
POLD2-polymerase (DNA directed), delta 2, regulatory subunit 50kDa-HPRD9286699 
POLD3KIAA0039 | MGC119642 | MGC119643 | P66 | P68polymerase (DNA-directed), delta 3, accessory subunit-HPRD10852724 
PTP4A3PRL-3 | PRL-R | PRL3protein tyrosine phosphatase type IVA, member 3Affinity Capture-MSBioGRID17353931 
RFC1A1 | MGC51786 | MHCBFB | PO-GA | RECC1 | RFC | RFC140replication factor C (activator 1) 1, 145kDa-HPRD,BioGRID9563011 
TREX2-three prime repair exonuclease 2in vitroBioGRID12806015 
 
KEGG Pathway Info
hsa00230: Purine metabolism - Homo sapiens (human)Go to KEGGAll SZGR genes in this pathway
hsa00240: Pyrimidine metabolism - Homo sapiens (human)Go to KEGGAll SZGR genes in this pathway
hsa03030: DNA replication - Homo sapiens (human)Go to KEGGAll SZGR genes in this pathway
hsa03410: Base excision repair - Homo sapiens (human)Go to KEGGAll SZGR genes in this pathway
hsa03420: Nucleotide excision repair - Homo sapiens (human)Go to KEGGAll SZGR genes in this pathway
hsa03430: Mismatch repair - Homo sapiens (human)Go to KEGGAll SZGR genes in this pathway
hsa03440: Homologous recombination - Homo sapiens (human)Go to KEGGAll SZGR genes in this pathway
 


Copyright © Bioinformatics Lab @ VIPBG, VCU All Rights Reserved.