Gene Page: PROC

Summary
GeneID  5624
Symbol  PROC
Synonyms  PC|PROC1
Description  protein C (inactivator of coagulation factors Va and VIIIa)
See related  HGNC:9451|MIM:612283|Ensembl:ENSG00000115718|HPRD:01466|
Locus tag  -
Gene type  protein-coding
Map location  2q13-q14
 
Gene in Data Sources
Gene set nameMethod of gene setEvidenceInfo
GSMA_Igenome scan meta-analysisPsr: 0.023 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00755 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
Gene Expression ?
 
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003824catalytic activityIEA-
GO:0004252serine-type endopeptidase activityIEAglutamate (GO term level: 7)-
GO:0004252serine-type endopeptidase activityTASglutamate (GO term level: 7)15005336 
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIPI15248212 
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisIEA-
GO:0006508proteolysisNAS12052963 
GO:0030195negative regulation of blood coagulationTAS15005336 
GO:0043066negative regulation of apoptosisIMP12563316 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionNAS14718574 
GO:0005634nucleusIDA18029348 
GO:0005730nucleolusIDA18029348 
GO:0005886plasma membraneEXP2538457 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CPCP-2ceruloplasmin (ferroxidase)-HPRD,BioGRID2105310 
F5FVL | PCCFcoagulation factor V (proaccelerin, labile factor)-HPRD1615482 
F8AHF | DXS1253E | F8B | F8C | FVIII | HEMAcoagulation factor VIII, procoagulant component-HPRD1761551 |1939075 
PF4CXCL4 | MGC138298 | SCYB4platelet factor 4Reconstituted ComplexBioGRID9395524 
PROCRCCCA | CCD41 | CD201 | EPCR | MGC23024 | bA42O4.2protein C receptor, endothelial (EPCR)-HPRD,BioGRID10681521 |11099506 
SERPINA5PAI3 | PCI | PLANH3 | PROCIserpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5-HPRD,BioGRID11123896 
THBDCD141 | THRM | TMthrombomodulin-HPRD11106601 |12588872 
 
KEGG Pathway Info
hsa04610: Complement and coagulation cascades - Homo sapiens (human)Go to KEGGAll SZGR genes in this pathway
 


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