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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: PROC

Summary

GeneID

5624

Symbol

PROC

Synonyms

PC|PROC1

Description

protein C (inactivator of coagulation factors Va and VIIIa)

See related

HGNC:9451|MIM:612283|Ensembl:ENSG00000115718|HPRD:01466|

Locus tag

-

Gene type

protein-coding

Map location

2q13-q14

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

genome scan meta-analysis

Psr: 0.023

genome scan meta-analysis (All samples)

Psr: 0.00755

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 2

Gene Expression ?

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

catalytic activity

IEA

-

serine-type endopeptidase activity

IEA

glutamate (GO term level: 7)

-

serine-type endopeptidase activity

TAS

glutamate (GO term level: 7)

calcium ion binding

IEA

-

protein binding

IPI

peptidase activity

IEA

-

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

proteolysis

IEA

-

proteolysis

NAS

negative regulation of blood coagulation

TAS

negative regulation of apoptosis

IMP

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

extracellular region

NAS

nucleus

IDA

nucleolus

IDA

plasma membrane

EXP

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CP	CP-2	ceruloplasmin (ferroxidase)	-	HPRD,BioGRID	2105310
F5	FVL \| PCCF	coagulation factor V (proaccelerin, labile factor)	-	HPRD	1615482
F8	AHF \| DXS1253E \| F8B \| F8C \| FVIII \| HEMA	coagulation factor VIII, procoagulant component	-	HPRD	1761551 \|1939075
PF4	CXCL4 \| MGC138298 \| SCYB4	platelet factor 4	Reconstituted Complex	BioGRID	9395524
PROCR	CCCA \| CCD41 \| CD201 \| EPCR \| MGC23024 \| bA42O4.2	protein C receptor, endothelial (EPCR)	-	HPRD,BioGRID	10681521 \|11099506
SERPINA5	PAI3 \| PCI \| PLANH3 \| PROCI	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	-	HPRD,BioGRID	11123896
THBD	CD141 \| THRM \| TM	thrombomodulin	-	HPRD	11106601 \|12588872

KEGG Pathway Info

hsa04610: Complement and coagulation cascades - Homo sapiens (human)

All SZGR genes in this pathway

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