Gene Page: PTGS1

Summary
GeneID  5742
Symbol  PTGS1
Synonyms  COX1|COX3|PCOX1|PGG/HS|PGHS-1|PGHS1|PHS1|PTGHS
Description  prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
See related  HGNC:9604|MIM:176805|Ensembl:ENSG00000095303|HPRD:07518|
Locus tag  RP11-542K23.6
Gene type  protein-coding
Map location  9q32-q33.3
 
Gene in Data Sources
Gene set nameMethod of gene setEvidenceInfo
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
Gene Expression ?
 
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004601peroxidase activityIEA-
GO:0004666prostaglandin-endoperoxide synthase activityTAS9630216 
GO:0005506iron ion bindingIEA-
GO:0016491oxidoreductase activityIEA-
GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenIEA-
GO:0020037heme bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001516prostaglandin biosynthetic processISS-
GO:0006629lipid metabolic processNAS1907252 
GO:0006633fatty acid biosynthetic processIEA-
GO:0006979response to oxidative stressIEA-
GO:0008217regulation of blood pressureISS-
GO:0055114oxidation reductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusISS-
GO:0005737cytoplasmISS-
GO:0005783endoplasmic reticulumIEA-
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005792microsomeISS-
GO:0005794Golgi apparatusIDA18029348 
GO:0005886plasma membraneIDA18029348 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
NUCB1DKFZp686A15286 | FLJ40471 | NUCnucleobindin 1Two-hybridBioGRID8643612 
PTGS1COX1 | COX3 | PCOX1 | PGG/HS | PGHS-1 | PGHS1 | PHS1 | PTGHSprostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)COX-1 forms a homodimer. This interaction was modelled on a demonstrated homodimerization of sheep COX-1.BIND11318639 
 
KEGG Pathway Info
hsa00590: Arachidonic acid metabolism - Homo sapiens (human)Go to KEGGAll SZGR genes in this pathway
 


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