Gene Page: TRAF6

Summary
GeneID  7189
Symbol  TRAF6
Synonyms  MGC:3310|RNF85
Description  TNF receptor-associated factor 6
See related  HGNC:12036|MIM:602355|Ensembl:ENSG00000175104|HPRD:03833|
Locus tag  -
Gene type  protein-coding
Map location  11p12
 
Gene in Data Sources
Gene set nameMethod of gene setEvidenceInfo
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.4462 
 
Gene Expression ?
 
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004842ubiquitin-protein ligase activityIDA15125833 
GO:0005515protein bindingIPI11244088 |11397809 |11751921 
|15125833 
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000209protein polyubiquitinationIDA15125833 
GO:0001503ossificationIEA-
GO:0001843neural tube closureIEA-
GO:0002726positive regulation of T cell cytokine productionIMP15125833 
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0006955immune responseIEA-
GO:0007165signal transductionIEA-
GO:0007250activation of NF-kappaB-inducing kinase activityIMP15125833 
GO:0009887organ morphogenesisIEA-
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class IIIEA-
GO:0032743positive regulation of interleukin-2 productionIMP15125833 
GO:0042088T-helper 1 type immune responseIEA-
GO:0042475odontogenesis of dentine-containing toothIEA-
GO:0042981regulation of apoptosisIEA-
GO:0043011myeloid dendritic cell differentiationIEAdendrite (GO term level: 10)-
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIEP12761501 
GO:0045084positive regulation of interleukin-12 biosynthetic processIEA-
GO:0045410positive regulation of interleukin-6 biosynthetic processIEA-
GO:0048468cell developmentIEA-
GO:0050852T cell receptor signaling pathwayIMP15125833 
GO:0050870positive regulation of T cell activationIC15125833 
GO:0051023regulation of immunoglobulin secretionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005624membrane fractionIEA-
GO:0005737cytoplasmIEA-
GO:0005829cytosolEXP9162092 |9744859 |10066798 
|10465784 |12138165 
|12609980 |15125833 
GO:0005829cytosolIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ASXL2ASXH2 | DKFZp686C1968 | FLJ10898 | KIAA1685additional sex combs like 2 (Drosophila)Affinity Capture-MSBioGRID17353931 
ATP2A2ATP2B | DAR | DD | DKFZp686P0211 | FLJ20293 | FLJ38063 | MGC45367 | SERCA2ATPase, Ca++ transporting, cardiac muscle, slow twitch 2-HPRD14743216 
CD40Bp50 | CDW40 | MGC9013 | TNFRSF5 | p50CD40 molecule, TNF receptor superfamily member 5Reconstituted ComplexBioGRID9384571 |9990007 
-HPRD10075662 |10411888 
CTPS-CTP synthaseAffinity Capture-MSBioGRID17353931 
DDX3XDBX | DDX14 | DDX3 | HLP2DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linkedAffinity Capture-MSBioGRID17353931 
ECSITSITPECECSIT homolog (Drosophila)-HPRD,BioGRID10465784 
EDA2REDA-A2R | EDAA2R | TNFRSF27 | XEDARectodysplasin A2 receptor-HPRD,BioGRID12060722 
EIF4E24E-LP | 4EHP | EIF4EL3 | IF4eeukaryotic translation initiation factor 4E family member 2Affinity Capture-MSBioGRID17353931 
EPPK1EPIPL | EPIPL1epiplakin 1Affinity Capture-MSBioGRID17353931 
GANABG2AN | GluII | KIAA0088glucosidase, alpha; neutral ABAffinity Capture-MSBioGRID17353931 
HSPA8HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71heat shock 70kDa protein 8-HPRD14743216 
IARSFLJ20736 | IARS1 | ILRS | PRO0785isoleucyl-tRNA synthetaseAffinity Capture-MSBioGRID17353931 
IL17RBCRL4 | EVI27 | IL17BR | IL17RH1 | MGC5245interleukin 17 receptor B-HPRD,BioGRID10748240 
IRAK1IRAK | pelleinterleukin-1 receptor-associated kinase 1TRAF6 interacts with IRAK1. This interaction was modeled on a demonstrated interaction between TRAF6 and IRAK1, both from unspecified species.BIND15894263 
-HPRD,BioGRID8837778 
IRAK2IRAK-2 | MGC150550interleukin-1 receptor-associated kinase 2IRAK-2 interacts with TRAF6.BIND10383454 
-HPRD,BioGRID9374458 
IRAK3ASRT5 | IRAK-M | IRAKMinterleukin-1 receptor-associated kinase 3IRAK-M interacts with TRAF6.BIND10383454 
-HPRD,BioGRID10383454 
IRAK4IPD1 | NY-REN-64 | REN64interleukin-1 receptor-associated kinase 4-HPRD,BioGRID11960013 
IRF7IRF-7H | IRF7Ainterferon regulatory factor 7IRF7 intereacts with TRAF6. This interaction was modeled on a demonstrated interaction between mouse IRF7 and human TRAF6.BIND15361868 
KCNQ1ATFB1 | FLJ26167 | JLNS1 | KCNA8 | KCNA9 | KVLQT1 | Kv1.9 | Kv7.1 | LQT | LQT1 | RWS | SQT2 | WRSpotassium voltage-gated channel, KQT-like subfamily, member 1Affinity Capture-MSBioGRID14743216 
MALT1DKFZp434L132 | MLT | MLT1mucosa associated lymphoid tissue lymphoma translocation gene 1TRAF6 interacts with MALT1. This interaction was modeled on a demonstrated interaction between TRAF6 from mouse and MALT1 from human.BIND15125833 
MAP3K14FTDCR1B | HS | HSNIK | NIKmitogen-activated protein kinase kinase kinase 14-HPRD,BioGRID11278268 
NIK interacts with TRAF6. This interaction was modeled on a demonstrated interaction between human NIK and TRAF6 from an unspecified species.BIND9275204 
MAP3K5ASK1 | MAPKKK5 | MEKK5mitogen-activated protein kinase kinase kinase 5-HPRD,BioGRID10523862 
MAP3K7TAK1 | TGF1amitogen-activated protein kinase kinase kinase 7-HPRD,BioGRID10094049 
MAP3K7IP13'-Tab1 | MGC57664 | TAB1mitogen-activated protein kinase kinase kinase 7 interacting protein 1-HPRD,BioGRID10094049 
MAP3K7IP2FLJ21885 | KIAA0733 | TAB2mitogen-activated protein kinase kinase kinase 7 interacting protein 2-HPRD,BioGRID10882101 
MAP3K7IP3MGC45404 | NAP1 | TAB3mitogen-activated protein kinase kinase kinase 7 interacting protein 3TAB3 interacts with TRAF6.BIND15327770 
-HPRD,BioGRID14633987 
MAST2FLJ39200 | KIAA0807 | MAST205 | MTSSK | RP4-533D7.1microtubule associated serine/threonine kinase 2-HPRD,BioGRID15308666 
MCM7CDABP0042 | CDC47 | MCM2 | P1.1-MCM3 | P1CDC47 | P85MCM | PNAS-146minichromosome maintenance complex component 7Affinity Capture-MSBioGRID17353931 
MTHFD1MTHFC | MTHFDmethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetaseAffinity Capture-MSBioGRID17353931 
NASPDKFZp547F162 | FLB7527 | FLJ31599 | FLJ35510 | MGC19722 | MGC20372 | MGC2297 | PRO1999nuclear autoantigenic sperm protein (histone-binding)Affinity Capture-MSBioGRID17353931 
NGFRCD271 | Gp80-LNGFR | TNFRSF16 | p75(NTR) | p75NTRnerve growth factor receptor (TNFR superfamily, member 16)-HPRD,BioGRID10514511 
NTSR1NTRneurotensin receptor 1 (high affinity)-HPRD10514511 
OTUD7BCEZANNE | ZA20D1OTU domain containing 7B-HPRD,BioGRID11463333 
-HPRD9928991 
PAICSADE2 | ADE2H1 | AIRC | DKFZp781N1372 | MGC1343 | MGC5024 | PAISphosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetaseAffinity Capture-MSBioGRID17353931 
PELI3MGC35521pellino homolog 3 (Drosophila)-HPRD12874243 
PFASFGAMS | FGARAT | KIAA0361 | PURLphosphoribosylformylglycinamidine synthaseAffinity Capture-MSBioGRID17353931 
PRKCZPKC-ZETA | PKC2protein kinase C, zeta-HPRD,BioGRID10747026 
PSMA4HC9 | HsT17706 | MGC111191 | MGC12467 | MGC24813 | PSC9proteasome (prosome, macropain) subunit, alpha type, 4-HPRD14743216 
PSMB5LMPX | MB1 | MGC104214 | Xproteasome (prosome, macropain) subunit, beta type, 5Affinity Capture-MSBioGRID14743216 
PSMC1MGC24583 | MGC8541 | P26S4 | S4 | p56proteasome (prosome, macropain) 26S subunit, ATPase, 1Affinity Capture-MSBioGRID14743216 
PSMC2MGC3004 | MSS1 | Nbla10058 | S7proteasome (prosome, macropain) 26S subunit, ATPase, 2Affinity Capture-MSBioGRID14743216 
PSMC3MGC8487 | TBP1proteasome (prosome, macropain) 26S subunit, ATPase, 3Affinity Capture-MSBioGRID14743216 
PSMD1MGC133040 | MGC133041 | P112 | Rpn2 | S1proteasome (prosome, macropain) 26S subunit, non-ATPase, 1-HPRD,BioGRID14743216 
PSMD12MGC75406 | Rpn5 | p55proteasome (prosome, macropain) 26S subunit, non-ATPase, 12-HPRD,BioGRID14743216 
PSMD13HSPC027 | Rpn9 | S11 | p40.5proteasome (prosome, macropain) 26S subunit, non-ATPase, 13Affinity Capture-MSBioGRID14743216 
PSMD3P58 | RPN3 | S3proteasome (prosome, macropain) 26S subunit, non-ATPase, 3-HPRD,BioGRID14743216 
PSMD4AF | AF-1 | ASF | MCB1 | Rpn10 | S5A | pUB-R5proteasome (prosome, macropain) 26S subunit, non-ATPase, 4-HPRD14743216 
PSMD7MOV34 | P40 | Rpn8 | S12proteasome (prosome, macropain) 26S subunit, non-ATPase, 7Affinity Capture-MSBioGRID14743216 
PSMD8HIP6 | HYPF | MGC1660 | Nin1p | Rpn12 | S14 | p31proteasome (prosome, macropain) 26S subunit, non-ATPase, 8-HPRD14743216 
RIPK2CARD3 | CARDIAK | CCK | GIG30 | RICK | RIP2receptor-interacting serine-threonine kinase 2-HPRD,BioGRID9642260 
RNF126FLJ20552 | MGC1022 | MGC14317ring finger protein 126-HPRD14743216 
SIGIRRMGC110992 | TIR8single immunoglobulin and toll-interleukin 1 receptor (TIR) domain-HPRD,BioGRID12925853 
SPOPTEF2speckle-type POZ protein-HPRD,BioGRID11279055 
SQSTM1A170 | OSIL | PDB3 | ZIP3 | p60 | p62 | p62Bsequestosome 1-HPRD,BioGRID10747026 |11244088 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID10635328 
STRADBALS2CR2 | CALS-21 | ILPIP | ILPIPA | MGC102916 | PAPK | PRO1038STE20-related kinase adaptor beta-HPRD,BioGRID12048196 
SYKDKFZp313N1010 | FLJ25043 | FLJ37489spleen tyrosine kinase-HPRD,BioGRID11418661 
TARSMGC9344 | ThrRSthreonyl-tRNA synthetaseAffinity Capture-MSBioGRID17353931 
TAX1BP1CALCOCO3 | T6BP | TXBP151Tax1 (human T-cell leukemia virus type I) binding protein 1-HPRD,BioGRID10920205 
TICAM1MGC35334 | PRVTIRB | TICAM-1 | TRIFtoll-like receptor adaptor molecule 1TRIF interacts with TRAF6.BIND14530355 
An unspecified isoform of TRIF interacts with TRAF6. This interaction was modeled on a demonstrated interaction between TRIF from an unspecified species and TRAF from an unspecified species.BIND15474016 
TICAM2MGC129876 | MGC129877 | TICAM-2 | TIRAP3 | TIRP | TRAMtoll-like receptor adaptor molecule 2-HPRD12721283 
TIRP interacts with TRAF6. This interaction was modeled on a demonstrated interaction between human TIRP and TRAF6 from an unspecified species.BIND12721283 
TIFAMGC20791 | T2BP | T6BP | TIFAATRAF-interacting protein with forkhead-associated domain-HPRD,BioGRID12566447 
TJP2MGC26306 | X104 | ZO-2 | ZO2tight junction protein 2 (zona occludens 2)Affinity Capture-MSBioGRID17353931 
TMEM189-UBE2V1CROC-1B | Kua-UEV | UBE2V1TMEM189-UBE2V1 readthrough transcript-HPRD,BioGRID11057907 
TNFAIP3A20 | MGC104522 | MGC138687 | MGC138688 | OTUD7C | TNFA1P2tumor necrosis factor, alpha-induced protein 3-HPRD,BioGRID9928991 
TNFRSF11ACD265 | FEO | LOH18CR1 | ODFR | OFE | OPTB7 | OSTS | PDB2 | RANK | TRANCERtumor necrosis factor receptor superfamily, member 11a, NFKB activatorAffinity Capture-Western
Reconstituted Complex
BioGRID9685412 |9852070 
|10025951 |10075662 
|11809792 
-HPRD9685412 |10025951 
|10075662 |10635328 
TNFRSF13BCD267 | CVID | FLJ39942 | MGC133214 | MGC39952 | TACI | TNFRSF14Btumor necrosis factor receptor superfamily, member 13B-HPRD,BioGRID10880535 
TNFRSF19TAJ | TAJ-alpha | TRADE | TROYtumor necrosis factor receptor superfamily, member 19-HPRD,BioGRID12060722 
TNFSF11CD254 | ODF | OPGL | OPTB2 | RANKL | TRANCE | hRANKL2 | sOdftumor necrosis factor (ligand) superfamily, member 11-HPRD10635328 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2Two-hybridBioGRID16189514 
TRAF6MGC:3310 | RNF85TNF receptor-associated factor 6TRAF6 interacts with itself and forms an oligomer.BIND15125833 
TRIM37KIAA0898 | MUL | POB1 | TEF3tripartite motif-containing 37-HPRD,BioGRID11279055 
TTRAPAD022 | EAP2 | MGC111021 | MGC9099 | dJ30M3.3TRAF and TNF receptor associated protein-HPRD,BioGRID10764746 
TUBA3CTUBA2 | bA408E5.3tubulin, alpha 3c-HPRD14743216 
TUBB2BDKFZp566F223 | FLJ98847 | MGC8685 | TUBB-PARALOG | bA506K6.1tubulin, beta 2B-HPRD14743216 
UBBFLJ25987 | MGC8385ubiquitin BTRAF6 interacts with Ub. This interaction was modeled on a demonstrated interaction between TRAF6 from mouse and Ub from an unspecified source.BIND15125833 
USP7HAUSP | TEF1ubiquitin specific peptidase 7 (herpes virus-associated)-HPRD,BioGRID11279055 
VARSG7A | VARS1 | VARS2valyl-tRNA synthetaseAffinity Capture-MSBioGRID17353931 
VCPIBMPFD | MGC131997 | MGC148092 | MGC8560 | TERA | p97valosin-containing proteinAffinity Capture-MSBioGRID17353931 
VDAC1MGC111064 | PORIN | PORIN-31-HLvoltage-dependent anion channel 1Affinity Capture-MSBioGRID17353931 
XIAPAPI3 | BIRC4 | ILP1 | MIHA | XLP2X-linked inhibitor of apoptosis-HPRD,BioGRID12048196 
ZFAND5ZA20D2 | ZFAND5A | ZNF216zinc finger, AN1-type domain 5Affinity Capture-WesternBioGRID14754897 
ZNF216 interacts with TRAF6. This interaction was modeled on a demonstrated interaction between human ZNF216 and TRAF6 from an unspecified species.BIND14754897 
ZNF675FLJ36350 | TBZF | TIZzinc finger protein 675-HPRD,BioGRID11751921 
ZRANB1DKFZp762P2216 | TRABIDzinc finger, RAN-binding domain containing 1-HPRD,BioGRID11463333 
 
KEGG Pathway Info
hsa04010: MAPK signaling pathway - Homo sapiens (human)Go to KEGGAll SZGR genes in this pathway
hsa04120: Ubiquitin mediated proteolysis - Homo sapiens (human)Go to KEGGAll SZGR genes in this pathway
hsa04620: Toll-like receptor signaling pathway - Homo sapiens (human)Go to KEGGAll SZGR genes in this pathway
hsa05222: Small cell lung cancer - Homo sapiens (human)Go to KEGGAll SZGR genes in this pathway
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1464734801A,m8hsa-miR-146aUGAGAACUGAAUUCCAUGGGUU
hsa-miR-146bbrainUGAGAACUGAAUUCCAUAGGCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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