What are tumor suppressor genes
Tumor suppressor genes (TSGs) are a group of guardian genes that play critical roles in controlling cell proliferation processes such as cell cycle checkpoints and apoptosis. They may influence cancer development by loss-of-function. Identification of these genes and understanding their functions is critical for further investigation of tumorigenesis. During the past three decades, numerous studies have been published regarding TSGs and how they function in various types of tumors. Furthermore, accumulating evidence has shown that microRNAs can act as tumor suppressors to prevent tumorigenesis processes.
Number of tumor suppressor genes in the database
716 human genes (637 coding and 79 non-coding genes), 628 mouse genes, and 567 rat genes
Our database allows
cancer researchers to search and browse the most comprehensive tumor suppressor gene list with literature evidence.
cancer researchers to access extensive annotations such as cancer mutations, gene expressions from hundreds of tumor and normal samples, methylation sites, and protein-protein interactions.
computational biologists to download coding and non-coding tumor suppressor genes for further analysis.
Min Zhao, Jingchun Sun, Zhongming Zhao (2013) TSGene: a web resource for tumor suppressor genes. Nucleic Acids Research, 41: D970-D976